Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. eLife 2014;3:e05151 [Pubmed]


Oliver JA, Lapinski PE, Lubeck BA, Turner JS, Parada LF, Zhu Y, King PD. The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes. Mol Immunol. 2013 Oct;55(3-4):292-302 [Pubmed]

Chenran Wang, Chun-Chi Liang, Z Christine Bian, Yuan Zhu and Jun-Lin Guan. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nature Neuroscience 16, 532–542 (2013) [Pubmed]

Jinsuke Nishino, Sunjung Kim, Yuan Zhu, Hao Zhu, Sean J Morrison. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. eLife 2013;2:e00924. [Pubmed]


Wang, Y., Kim, E., Wang, X., Novitch, B.G., Yoshikawa, K., Chang, L.S. and Zhu, Y. ERK Inhibition Rescues Defects in Fate Specification of Nf1 Deficient Neural Progenitors and Brain Abnormalities. Cell. 2012 Aug 17;150(4):816-30. [Pubmed]


Tan M, Zhao Y, Kim SJ, Liu M, Jia L, Saunders TL, Zhu Y*, Sun Y.* SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell. 2011 Dec 13;21(6):1062-76 (*Co-corresponder authors) [Pubmed]

Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG. Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A. 2011 February ; 155A(2): 307–321. [Pubmed]


Wang, Y.*, Yang, J.*, Zheng, H., Tomasek, G.J., Zhang, P., McKeever, P.E., Lee, E.P. and Zhu, Y. (2009). Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell, 15(6):514-26. (*These authors contributed equally to this work) [Pubmed]

Tan, M., Davis, S.W., Saunders, T.L., Zhu, Y. and Sun, Y. (2009).  RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simutaneous loss of p27.  PNAS, 106(15):6203-8. [Pubmed]


Yang, F.C., Ingram, D.A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S.T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L.F. and Clapp, D.W. (2008). Nf1-dependent tumors require a microenvironment containing Nf1+/– and c-kit-dependent bone marrow. Cell, 135(3):437-48.[PubMed]

Cui, Y., Costa, R.M., Murphy, G.G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I. and Silva, A.J. (2008). Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell, 135(3):549-560. [PubMed]

Zheng, H.*, Chang, L.*, Patel, N., Yang, J., Lowe, L., Burns, D.K. and Zhu, Y. (2008). Induction of abnormal proliferation by non-myelinating Schwann cells triggers neurofibroma formation. Cancer Cell, 13: 117-128 (*These authors contributed equally to this work) [PubMed]

Joseph, N.M., Mosher, J.T., Buchstaller, J., Snider, P., McKeever, P.E., Lim, M., Conway, S.J., Parada, L.F., Zhu, Y and Morrison, S.J. (2008). The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells., Cancer Cell, 13: 129-140 [PubMed]

Roth, T.M., Ramamurthy, P., Muir, D., Wallace, M.R., Zhu, Y., Chang, L. and Barald, K.F. (2008). Influence of hormones and hormone metabolites on the growth of Schwann Cells derived from embryonic stem cells and tumor cell lines expressing variable levels of neurofibromin. Development Dynamics, 237(2):  513-524  [PubMed]


Romero, M.I., Lu, M., Lush, M.E., Lei, L., Parada L.F. and Zhu, Y. (2007). Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. Journal of Neuroscience, 27 (8): 2124-2134. [Pubmed]


Parada L.F., Kwon C.H. and Zhu Y. (2005). Modeling neurofibromatosis type 1 tumors in the mouse for therapeutic intervention. Cold Spring Harbor Symposia on Quantitative Biology, 70: 173-6.

Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D. K., Mason, R. P., and Parada, L. F (2005). Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.
Cancer Cell, 8 (2):119-130. [Pubmed]

Zhu, Y.*, Harada, T., Liu, L., Lush, M.E., Guignard, F., Harada, C., Burns, D.K., Bajenaru, M.L., Gutmann, D.H. and Parada, L.F. (2005). Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development, 132 (24):5577-88 (*Corresponding author).[Pubmed]


Gitler, A.D., Kong, Y., Choi, J.K., Zhu, Y., Pear, W.S. and Epstein, J.A. (2004). Tie2-Cre-Induced Inactivation of a Conditional Mutant Nf1 Allele in Mouse Results in a Myeloproliferative Disorder that Models Juvenile Myelomonocytic Leukemia. Pediatric Research, 55 (4):581-4. [Pubmed]

Le, D.T., Kong, N., Zhu, Y., Lauchle, J.O., Aiyigari, A., Braun, B.S., Wang, E., Kogan, S.C., LeBeau M.M., Parada, L. and Shannon, K.M. (2004). Somatic Inactivation of Nf1 in Hematopoietic Cells Results in a Progressive Myeloproliferative Disorder. Blood, 103 (11):4243-50. [Pubmed]

Stemmer-Rachamimov, A.O., Louis, D.N., Nielsen, G.P., Antonescu, C., Borowsky, A., Bronson, R., Burns, D.K., Cervera, P., McLaughlin, M., Reifenberger, G., Schmale, M., MacCollin M., Chao, R., Cichowski, K., Kalamarides M., Kumar, S., McClatchey, A., Niwa-Kawakita, M., Ratner, N., Reilly, K., Zhu, Y. and Giovannini, M. (2004). Comparative pathology of nerve sheath tumors in mouse models and humans.
Cancer Research, 64 (10):3718-24. [Pubmed]


Gitler, A.D.*, Zhu, Y.*, Ismat, F.A., Lu, M.M., Yamauchi, Y., Parada, L.F. and Epstein, J.A. (2003). The type 1 Neurofibromatosis (Nf1) gene product has distinct and essential roles in neural crest and endothelial cells.
Nature Genetics
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Bajenaru, M.L., Hernandez, M.R., Perry, A., Zhu, Y., Parada, L.F., Garbow, J.R. and Gutmann, D.H. (2003). Optic nerve glioma in mice requires astrocyte NF1 inactivation and NF1 brain heterozygosity.
Cancer Research
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Zhu,Y., Ghosh, P., Charnay, Burns, D.K. and Parada, L.F. (2002). Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science, 296 (5569):920-922. [Pubmed]

Bajenaru, M.L., Zhu, Y., Hedrick, N.M., Donahoe, J. Parada, L.F. and Gutmann, D.H. (2002). Astrocyte-specific inactivation of the Neurofibromatosis 1(NF1) gene is insufficient for astrocytoma formation.
Molecular Cellular Biology, 22 (14):5100-5113. [Pubmed]

Zhu, Y. and Parada, L.F. (2002).Molecular biology and genetics of neurologic tumors.
Nature Reviews Cancer
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Zhu, Y. and Parada, L.F. (2001). Neurofibromin, a tumor suppressor in the nervous system.
Experimental Cell Research
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Zhu, Y. and Parada, L.F. (2001). A special GAP in mind (News and Views).
Nature Genetics, 27 (4):354-355. [Pubmed]

Zhu,Y., Romero, M., Ghosh, P., Ye, Z., Charnay, P., Rushing, E.J., Marth, J.D. and Parada, L.F. (2001). Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.
Genes & Development, 15 (7):859-876. [Pubmed]

Gutmann, D.H., Wu, Y.L., Hedrick, N.M, Zhu, Y.,Guha, A. and Parada, L.F. (2001). Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes. Human Molecular Genetics, 10 (26):3009-3016. [Pubmed]


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